This blog is devoted to BIOL 6988, a graduate level seminar in the biological sciences at Youngstown State University. While targeted towards graduate students, BIOL 6988 actively incorporates undergraduate participants in their scholastic endeavors in the biological sciences. This blog is intended as a educational tool not just for YSU students and faculty, but for anyone who wishes to contribute to an active-learning environment.
I have seen Dr. Walker present his research before but I never saw him discuss the evolutionary side of it. I found it really enjoyable and I didn't consider before the relevance of the evolutionary development of titin in it's function. I still find it fascinating that our body does so much work just to perform everyday routines and motions.
So often we hear about Titin and it's effects in basic functions but it was really cool to get a little bit more in depth with Dr. Walkers research. I agree with Ludmila, the evolutionary side of it was an interesting piece that I hadn't considered before. It would be interesting to mathematically analyze spring potentials of Titin to figure out just how it does what it does.
I agree that the evolution of titin was interesting to learn about. However, the effect of titin in muscle contraction on a mechanistic level peaked my interest. Particularly, the effects of phosphorylation and the protein kinase domains in titin. I was already aware that muscle contraction depends on a phosphorylase kinase enzyme being phosphorylated and having bound calcium ions. However, I never considered the effects of the phosphorylation of titin, which is connected to the contractile units in muscle, and how that generates contraction/relaxation.
I have seen Dr. Walker present his research before but I never saw him discuss the evolutionary side of it. I found it really enjoyable and I didn't consider before the relevance of the evolutionary development of titin in it's function. I still find it fascinating that our body does so much work just to perform everyday routines and motions.
ReplyDeleteSo often we hear about Titin and it's effects in basic functions but it was really cool to get a little bit more in depth with Dr. Walkers research. I agree with Ludmila, the evolutionary side of it was an interesting piece that I hadn't considered before. It would be interesting to mathematically analyze spring potentials of Titin to figure out just how it does what it does.
ReplyDeleteI agree that the evolution of titin was interesting to learn about. However, the effect of titin in muscle contraction on a mechanistic level peaked my interest. Particularly, the effects of phosphorylation and the protein kinase domains in titin. I was already aware that muscle contraction depends on a phosphorylase kinase enzyme being phosphorylated and having bound calcium ions. However, I never considered the effects of the phosphorylation of titin, which is connected to the contractile units in muscle, and how that generates contraction/relaxation.
ReplyDelete