This blog is devoted to BIOL 6988, a graduate level seminar in the biological sciences at Youngstown State University. While targeted towards graduate students, BIOL 6988 actively incorporates undergraduate participants in their scholastic endeavors in the biological sciences. This blog is intended as a educational tool not just for YSU students and faculty, but for anyone who wishes to contribute to an active-learning environment.
Dr. Fagan made me realized that there are a lot of ways to get to graduate school through her academic journey. She went on to explain how phage display is used to detect specific ligands for the treatment of diseases after scientist discovered that monoclonal antibodies from mice are stimulating immune response in humans and they are as well not binding effectively.
What do you think is the future of phage display technology? Do you see it making a great impact in the world or you think there could be problems arising with this technology in the future?
I love that Dr. Fagan also provided us with some background information on how she got the where she is today. I think learning about how our instructors found their path in life is very inspiring and motivating to know there is no right or wrong way to accomplish our goals.
I think the future of this technology can be very promising, especially with being able to recgonize blood loss. Assuming this technology/technique advances successfully this could have military applicaitons and use within the medical field. As with most things in life, it will most likely be a long road with obstacles to overcome, but assuming this becomes functional in the real world it could have huge implications. Beyond being able to recognize blood loss it could be specialized for a multitude of conditions/diseases to treat/respond to.
I found Dr. Fagan's talk really interesting. I had never considered that this technology could be used to detect if someone has been injured (blood loss) and then transmit an alert signal to first re-sponders.
I believe that this technology will have a bright future. It looks like a promising way to treat disease as well as have other interesting applications. However, like with all technology I'm sure there is a way to 'negatively' use it. All in all, like with most technology, I'm sure it will be an invaluable tool for humanity.
Dr. Fagan's talk was quite enlightening. I had not yet known of phage display or its capabilities.
I think that this technology is potentially very powerful, and that being able to build proteins that can selective bind to basically anything you want has the capability of accomplishing extraordinary things, as well as terrifying ones. This level of selectivity might one day allow us to "hand-craft" the binding sites on antibodies or chemotherapeutic agents to selectively target cancer cells or even viruses themselves. Right now, we are only in the early stages of phage display technology, and are compiling libraries of peptides with corresponding data about what they bind to. In the future, there is the possibility of compiling all this data into an analysis that would allow you to input what ever you wanted tagged, maybe a protein expressed on the surface of a cancer cell, or maybe a specific phenotypic trait, and the computer would be able to spit out a polypeptide sequence that when built, could selectively and tightly bind the target. The possibilities are daunting.
I completely agree with Anna's statement about speaker's incorporating their journey into their seminars! It is something that I find to be engaging and like Anna, inspiring.
Phage display technology is very interesting. I found Dr. Fagan's seminar to be incredibly informative, I have heard of phage display technology but didn't realize the potential it has to so heavily implicate science. I think there are endless possibilities to improve science and medicine through its usage. Craig and Erich both hit such home runs with phrasing it as invaluable and suggesting the possibility of "hand-crafting". I am slightly uneasy as I anticipate there will be several glitches, dead ends, and kinks to be worked through. However, that concept does apply to all aspects of our lives and work. Overall, I think that phage display technology is on the verge of being a major breakthrough for science. I am excited to see how it progresses and how it impacts science!
I, too, agree with Anna. The fact that Dr. Fagan incorporated her path to where she is now is very inspiring and helpful. It was nice to hear that there isn't just one way to reach your goal and be successful in life.
I found phage display technology to be very interesting since, I didn't know that they are hoping to use it for military and first responders injured in the field to get them help quickly by alerting an injury. However, as beneficial as phage display can be, it could also be detrimental. There is always someone out there that can take something great and do very bad things with it. I see a bright future for phage display technologies and am interested in seeing how it impacts the world.
Dr. Fagan's Topics in Microbiology course I am currently in has had a focus on phage display. The process of phage display seems like a really solid tool capable of being used in many applications. I am currently researching an article for the Topics class that uses phage display to find an antibody fragment that is able to bind to a specific site on malfunctioning enzymes that produce oncometabolites. When the antibody fragment attaches to the malfunctioning enzyme it is able to regain some lost control and stop oncometabolite production. The process of the Phage Display cycle allows for specific interactions to be studied and opens up many doors to discovering new methods of dealing with problems.
While I am not very familiar with Phage Display tech, I do know that it is immensely useful when determining different protein to DNA, protein to protein, and protein to peptide interactions. I think the future of Phage Display Tech will be its continue use in immunotherapy and in tumor recognition. Phage Display provides a high-throughput technique to screen different epitopes in side of a tumor or on the surface. This could help with early detection and possibly lead to different treatment modalities. As for possible problems that could arise from the use of this technology, i'm not really sure of what could happen. Im sure however, that hindsight the possible problems and issues with Phage Display Tech would be obvious.
Being able to learn about Dr. Fagan's journey was very interesting because she experienced so many different things to get to where she is today.
I did not know there was such strong advancements in phage display technology and I think the future for this field is very promising. The idea that this can be utilized for detecting injuries is amazing to even think about and the fact that it can be done is even better. Like Anna said, there are going to be obstacles that phage display technology will face but that is just like what any other discovery has to deal with. The long term outcome and its benefits far outweigh the drawbacks of dealing with any failures it would face to reach the ultimate goal.
First off, I enjoyed Dr. Fagan's presentation on her research and her unique journey. I thought it was interesting how she took a break from her education to work in a lab, and then later continued. As for phage display, I feel that it will most certainly have important roles in the future. Being able to use phage display to selectively bind antibodies to target molecules will definitely impact medicine and save more lives. Also, the uses for detecting injuries, as said by Anna, may be important for people in the military, or even for the police. Although there may be uses of this technology that could be problematic, I think for the most part, it will be important benefit to society.
Dr. Fagan's presentation was very informative. The journey throughout her academic life made me know why she is soo hard working. I admire even how she lectures having a chance to be in her class and lab. On Thywill question, Phage display technology is a very valuable tool in the biomedical and military fields since it provides rapid, efficient and relatively inexpensive method for identifying receptor sites, epitopes and mimotopes. This technology therefore exicites scientists who wish to explore the different mechanism of the disease, find efficient diagnostic method for a particular disease and finally design a therapeutic agent and vaccine. with phage display even the deadly disease such as cancer could find a cure one day since specific peptides targeting a particular tumor cell could be coupled to a toxin or a vaccine hence inhibit its growth.
I saw George's dissertation where he used the carbon nanotubes and phage display. I thought it was a really good way to bring the world of engineering into the world of biology. I also like that Dr. Fagan educated us on her background, as well as the different ways that phage display technology can be used today. I do not see any issues, yet, with phage display technology and believe there could be a great future with it. As Steficah said, I believe it can be used in cancer research, among many many other aspects. As I have seen, the field of engineering even used phage display technology for the carbon nanotubes dissertation.
Dr. Fagan made me realized that there are a lot of ways to get to graduate school through her academic journey. She went on to explain how phage display is used to detect specific ligands for the treatment of diseases after scientist discovered that monoclonal antibodies from mice are stimulating immune response in humans and they are as well not binding effectively.
ReplyDeleteWhat do you think is the future of phage display technology? Do you see it making a great impact in the world or you think there could be problems arising with this technology in the future?
I love that Dr. Fagan also provided us with some background information on how she got the where she is today. I think learning about how our instructors found their path in life is very inspiring and motivating to know there is no right or wrong way to accomplish our goals.
DeleteI think the future of this technology can be very promising, especially with being able to recgonize blood loss. Assuming this technology/technique advances successfully this could have military applicaitons and use within the medical field. As with most things in life, it will most likely be a long road with obstacles to overcome, but assuming this becomes functional in the real world it could have huge implications. Beyond being able to recognize blood loss it could be specialized for a multitude of conditions/diseases to treat/respond to.
I found Dr. Fagan's talk really interesting. I had never considered that this technology could be used to detect if someone has been injured (blood loss) and then transmit an alert signal to first re-sponders.
ReplyDeleteI believe that this technology will have a bright future. It looks like a promising way to treat disease as well as have other interesting applications. However, like with all technology I'm sure there is a way to 'negatively' use it. All in all, like with most technology, I'm sure it will be an invaluable tool for humanity.
Dr. Fagan's talk was quite enlightening. I had not yet known of phage display or its capabilities.
ReplyDeleteI think that this technology is potentially very powerful, and that being able to build proteins that can selective bind to basically anything you want has the capability of accomplishing extraordinary things, as well as terrifying ones. This level of selectivity might one day allow us to "hand-craft" the binding sites on antibodies or chemotherapeutic agents to selectively target cancer cells or even viruses themselves. Right now, we are only in the early stages of phage display technology, and are compiling libraries of peptides with corresponding data about what they bind to. In the future, there is the possibility of compiling all this data into an analysis that would allow you to input what ever you wanted tagged, maybe a protein expressed on the surface of a cancer cell, or maybe a specific phenotypic trait, and the computer would be able to spit out a polypeptide sequence that when built, could selectively and tightly bind the target. The possibilities are daunting.
I completely agree with Anna's statement about speaker's incorporating their journey into their seminars! It is something that I find to be engaging and like Anna, inspiring.
ReplyDeletePhage display technology is very interesting. I found Dr. Fagan's seminar to be incredibly informative, I have heard of phage display technology but didn't realize the potential it has to so heavily implicate science. I think there are endless possibilities to improve science and medicine through its usage. Craig and Erich both hit such home runs with phrasing it as invaluable and suggesting the possibility of "hand-crafting". I am slightly uneasy as I anticipate there will be several glitches, dead ends, and kinks to be worked through. However, that concept does apply to all aspects of our lives and work. Overall, I think that phage display technology is on the verge of being a major breakthrough for science. I am excited to see how it progresses and how it impacts science!
I, too, agree with Anna. The fact that Dr. Fagan incorporated her path to where she is now is very inspiring and helpful. It was nice to hear that there isn't just one way to reach your goal and be successful in life.
ReplyDeleteI found phage display technology to be very interesting since, I didn't know that they are hoping to use it for military and first responders injured in the field to get them help quickly by alerting an injury. However, as beneficial as phage display can be, it could also be detrimental. There is always someone out there that can take something great and do very bad things with it. I see a bright future for phage display technologies and am interested in seeing how it impacts the world.
Dr. Fagan's Topics in Microbiology course I am currently in has had a focus on phage display. The process of phage display seems like a really solid tool capable of being used in many applications. I am currently researching an article for the Topics class that uses phage display to find an antibody fragment that is able to bind to a specific site on malfunctioning enzymes that produce oncometabolites. When the antibody fragment attaches to the malfunctioning enzyme it is able to regain some lost control and stop oncometabolite production. The process of the Phage Display cycle allows for specific interactions to be studied and opens up many doors to discovering new methods of dealing with problems.
ReplyDeleteWhile I am not very familiar with Phage Display tech, I do know that it is immensely useful when determining different protein to DNA, protein to protein, and protein to peptide interactions. I think the future of Phage Display Tech will be its continue use in immunotherapy and in tumor recognition. Phage Display provides a high-throughput technique to screen different epitopes in side of a tumor or on the surface. This could help with early detection and possibly lead to different treatment modalities. As for possible problems that could arise from the use of this technology, i'm not really sure of what could happen. Im sure however, that hindsight the possible problems and issues with Phage Display Tech would be obvious.
ReplyDeleteBeing able to learn about Dr. Fagan's journey was very interesting because she experienced so many different things to get to where she is today.
ReplyDeleteI did not know there was such strong advancements in phage display technology and I think the future for this field is very promising. The idea that this can be utilized for detecting injuries is amazing to even think about and the fact that it can be done is even better. Like Anna said, there are going to be obstacles that phage display technology will face but that is just like what any other discovery has to deal with. The long term outcome and its benefits far outweigh the drawbacks of dealing with any failures it would face to reach the ultimate goal.
First off, I enjoyed Dr. Fagan's presentation on her research and her unique journey. I thought it was interesting how she took a break from her education to work in a lab, and then later continued. As for phage display, I feel that it will most certainly have important roles in the future. Being able to use phage display to selectively bind antibodies to target molecules will definitely impact medicine and save more lives. Also, the uses for detecting injuries, as said by Anna, may be important for people in the military, or even for the police. Although there may be uses of this technology that could be problematic, I think for the most part, it will be important benefit to society.
ReplyDeleteDr. Fagan's presentation was very informative. The journey throughout her academic life made me know why she is soo hard working. I admire even how she lectures having a chance to be in her class and lab.
ReplyDeleteOn Thywill question, Phage display technology is a very valuable tool in the biomedical and military fields since it provides rapid, efficient and relatively inexpensive method for identifying receptor sites, epitopes and mimotopes. This technology therefore exicites scientists who wish to explore the different mechanism of the disease, find efficient diagnostic method for a particular disease and finally design a therapeutic agent and vaccine.
with phage display even the deadly disease such as cancer could find a cure one day since specific peptides targeting a particular tumor cell could be coupled to a toxin or a vaccine hence inhibit its growth.
I saw George's dissertation where he used the carbon nanotubes and phage display. I thought it was a really good way to bring the world of engineering into the world of biology.
ReplyDeleteI also like that Dr. Fagan educated us on her background, as well as the different ways that phage display technology can be used today.
I do not see any issues, yet, with phage display technology and believe there could be a great future with it. As Steficah said, I believe it can be used in cancer research, among many many other aspects. As I have seen, the field of engineering even used phage display technology for the carbon nanotubes dissertation.