This blog is devoted to BIOL 6988, a graduate level seminar in the biological sciences at Youngstown State University. While targeted towards graduate students, BIOL 6988 actively incorporates undergraduate participants in their scholastic endeavors in the biological sciences. This blog is intended as a educational tool not just for YSU students and faculty, but for anyone who wishes to contribute to an active-learning environment.
Today, Steficah
Maosa, who is a grad student of Dr. Fagan, will be presenting at seminar.The title of her talk is “Using Phage Display
Technology to Produce Peptides Specific for Staphylococcus aureus, Type
8”.Please give her your full support!
I enjoyed Steficah's presentation and found her work to be very interesting. After Dr. Fagan's presentation, we discussed the endless possibilities of phage display technology. Steficah's presentation is such a great example of the amazing things we can do with this scientific technology. Staphylococcus aureus is responsible for infection and can be transmitted in three ways. As immunity for the treatments begins to grow, we need to come across a new method for controlling the bacteria.
What type of treatment do you think can stem from the ability to produce peptides specific for S. aureus type 5 and type 8? Do you think we could eventually use this technique to produce treatments for things like asthma, cancer and epilepsy? Could lead us toward eliminating infections caused by S. aureus and other bacteria?
I agree with Jessica. The possibilities of phage display are endless and if they can be used to target specific bacteria, numerous diseases can be cured faster with less antibiotic use. If they can create peptides specific for type 5 and type 8, scientists should be able to target those bacteria causing infections and control the infection, possibly cure it. I think it could be used to treat bacterial infections, discovering the antibodies to help with asthma, and to engineer proteins to control the inflammation for epilepsy. I believe it is being used to determine tumor antigens for diagnosing and determining therapeutic treatments in cancer. There are amazing things in store for this technology in the future.
I may have misinterpreted Ms. Maosa's presentation, but there seems like there could be a lot of potential using phage display technology when treating nosocomial infections. This would not only impact the patients quality of life, but also their finances. The CDDEP estimates the cost of these infections to be around 10 billion annually. As Hillari said, there is also the potential to develop new treatment modalities which would decrease the need for the use of antibiotics and combat antibiotic resistant strains. As for its uses in treating asthma, if there are therapies developed then that would open the door to treat more serious inflammation based diseases like cancer. More interstitial however, would be to prevent the development of certain cancers, that develop from inflammation pathways.
I also agree that as resistance begins to grow that we will need to come up with alternative therapies to combat the bacteria. I think there is a possibility to do combination therapies with a discovery from the phage display technology. This could aid in reducing the resistance by not having to use antibiotics in order to treat things like asthma. I believe these kinds of disorders can be treated in the future because there is such a promising outlook with this form of technology. Hopefully this could also lead to eliminating these infections from S.aureus as well.
I also enjoyed Steficah’s presentation last week. I thought it was an interesting approach to test the phage against S. aureus type 5 and type 8 capsular polysaccharides. Hopefully, treatments using this technology will lower the high mortality and morbidity rates of acquired S. aureus infections in hospitals and communities in the future. Perhaps treatments for conditions such as osteomyelitis, septicemia, or even endovascular infections could be developed to target antibiotic resistant strains of S. aureus that may cause these illnesses. These techniques may also become important for the treatment of certain types of cancer, where phage-displayed peptides can perhaps target tumor cells. Overall, phage display has great potential and may have a promising future in medicine.
One thing that stood out to me in Steficah's presentation was what she had to do when her results turned up unlike she expected. She made some modifications and got better results. I feel this is more accurate than what we see when we read about experiments in scientific journals and more closely reflects the true trial and error nature of science. I believe that finding specific peptides to type 5&8 is a great step forward in developing treatments to S. aureus. Phage display lets us modify and study proteins, bacteria, and cancerous cells. It seems to have a wide array of possibilities.
It will be interesting to see how this science advances in the future. The abiity to target a specific strain of bacteria holds a large potential for future healthcare applications. I'm not sure how this could be modified to treat asthma, cancer, or eplipsey unless they find a bacterial or pathogenic cause of the disease state. Although, it's hard to say what the future holds and how technology will advance I can definitely see an application for this in the treatment of infection caused by bacteria. This may someday advance to the predominant treatment for a bacterial infection as antibiotic resistance increases.
As antibacterial resistance continues to be an increasing problem in today's world, this technology to treat specific pathogens becomes more and more valuable. Being able to use these peptides to treat S.aureus looks like a promising technology. Phage display will be able to help us fight antibiotic resistance in various pathogens and this technology is quite impressive.
I found Steficah's research to be very interesting! I am curious to see how phage display technology advances in the future. I know that antibiotic resistance is becoming more of an issue, due to the amount of antibiotics that people now take and how it disrupts our natural gut microbiome. The idea that there could be specific strains targeted is huge, especially in treating S. aureus, among other bacterial strains. I believe it could lead us towards being able to fully treat such infections, as well as treating asthma, cancer, epilepsy, etc. Phage display has always been a topic of major interest to myself, and I am very interested to see how it progresses in the near future.
I enjoyed Steficah's presentation and found her work to be very interesting. After Dr. Fagan's presentation, we discussed the endless possibilities of phage display technology. Steficah's presentation is such a great example of the amazing things we can do with this scientific technology. Staphylococcus aureus is responsible for infection and can be transmitted in three ways. As immunity for the treatments begins to grow, we need to come across a new method for controlling the bacteria.
ReplyDeleteWhat type of treatment do you think can stem from the ability to produce peptides specific for S. aureus type 5 and type 8? Do you think we could eventually use this technique to produce treatments for things like asthma, cancer and epilepsy? Could lead us toward eliminating infections caused by S. aureus and other bacteria?
I agree with Jessica. The possibilities of phage display are endless and if they can be used to target specific bacteria, numerous diseases can be cured faster with less antibiotic use. If they can create peptides specific for type 5 and type 8, scientists should be able to target those bacteria causing infections and control the infection, possibly cure it. I think it could be used to treat bacterial infections, discovering the antibodies to help with asthma, and to engineer proteins to control the inflammation for epilepsy. I believe it is being used to determine tumor antigens for diagnosing and determining therapeutic treatments in cancer. There are amazing things in store for this technology in the future.
ReplyDeleteI may have misinterpreted Ms. Maosa's presentation, but there seems like there could be a lot of potential using phage display technology when treating nosocomial infections. This would not only impact the patients quality of life, but also their finances. The CDDEP estimates the cost of these infections to be around 10 billion annually. As Hillari said, there is also the potential to develop new treatment modalities which would decrease the need for the use of antibiotics and combat antibiotic resistant strains. As for its uses in treating asthma, if there are therapies developed then that would open the door to treat more serious inflammation based diseases like cancer. More interstitial however, would be to prevent the development of certain cancers, that develop from inflammation pathways.
ReplyDeleteI also agree that as resistance begins to grow that we will need to come up with alternative therapies to combat the bacteria. I think there is a possibility to do combination therapies with a discovery from the phage display technology. This could aid in reducing the resistance by not having to use antibiotics in order to treat things like asthma. I believe these kinds of disorders can be treated in the future because there is such a promising outlook with this form of technology. Hopefully this could also lead to eliminating these infections from S.aureus as well.
ReplyDeleteI also enjoyed Steficah’s presentation last week. I thought it was an interesting approach to test the phage against S. aureus type 5 and type 8 capsular polysaccharides. Hopefully, treatments using this technology will lower the high mortality and morbidity rates of acquired S. aureus infections in hospitals and communities in the future. Perhaps treatments for conditions such as osteomyelitis, septicemia, or even endovascular infections could be developed to target antibiotic resistant strains of S. aureus that may cause these illnesses. These techniques may also become important for the treatment of certain types of cancer, where phage-displayed peptides can perhaps target tumor cells. Overall, phage display has great potential and may have a promising future in medicine.
ReplyDeleteOne thing that stood out to me in Steficah's presentation was what she had to do when her results turned up unlike she expected. She made some modifications and got better results. I feel this is more accurate than what we see when we read about experiments in scientific journals and more closely reflects the true trial and error nature of science.
ReplyDeleteI believe that finding specific peptides to type 5&8 is a great step forward in developing treatments to S. aureus. Phage display lets us modify and study proteins, bacteria, and cancerous cells. It seems to have a wide array of possibilities.
It will be interesting to see how this science advances in the future. The abiity to target a specific strain of bacteria holds a large potential for future healthcare applications. I'm not sure how this could be modified to treat asthma, cancer, or eplipsey unless they find a bacterial or pathogenic cause of the disease state. Although, it's hard to say what the future holds and how technology will advance I can definitely see an application for this in the treatment of infection caused by bacteria. This may someday advance to the predominant treatment for a bacterial infection as antibiotic resistance increases.
ReplyDeleteAs antibacterial resistance continues to be an increasing problem in today's world, this technology to treat specific pathogens becomes more and more valuable. Being able to use these peptides to treat S.aureus looks like a promising technology. Phage display will be able to help us fight antibiotic resistance in various pathogens and this technology is quite impressive.
ReplyDeleteI found Steficah's research to be very interesting! I am curious to see how phage display technology advances in the future. I know that antibiotic resistance is becoming more of an issue, due to the amount of antibiotics that people now take and how it disrupts our natural gut microbiome. The idea that there could be specific strains targeted is huge, especially in treating S. aureus, among other bacterial strains. I believe it could lead us towards being able to fully treat such infections, as well as treating asthma, cancer, epilepsy, etc. Phage display has always been a topic of major interest to myself, and I am very interested to see how it progresses in the near future.
ReplyDelete