This blog is devoted to BIOL 6988, a graduate level seminar in the biological sciences at Youngstown State University. While targeted towards graduate students, BIOL 6988 actively incorporates undergraduate participants in their scholastic endeavors in the biological sciences. This blog is intended as a educational tool not just for YSU students and faculty, but for anyone who wishes to contribute to an active-learning environment.
I enjoyed the information provided at the end of his lecture in regards to where his past grad students are now. It is interesting to see how YSU Alumni have progressed in their careers post-graduation and how lab work and the mastering of lab techniques helped them in their careers. Something that is not always given a lot of thought when going through the daily struggle of grad school.
Dr. Asch gave a very interesting talk on the research going on in his lab. He does a lot of work with the model organism, Neurospora crassa, which grows rapidly, is easy to culture, and requires minimum growth media. Dr. Asch looks specifically at the effects of quinic acid and dextrose exposure on N. crassa. He uses a variety of analysis techniques for his samples including mass spectrometry and qRT-PCR with fluorescent markers. The use of bioinformatics is very critical to the analysis, so he works closely with Dr. Min.
In your opinion, if, there was not model organisms, such as Neurospora crassa, how would scientific research be effected?
As the semester draws to a close, its good to see that regardless of the path each speaker took, or how long it took them to reach their goals, they eventually were able to reach their academic or professional goals. It gives me a sense of hope to know that all the time and resources i'm investing will pay dividends down the road.
Another overarching theme amongst presenters was their use of molecular biology, bioinformatics, and statistics as tools to provide them with useful data for analysis. Dr. Asch utilized microarrys to do bulk expression analysis on Quinic Acid expression. however, Dr. Asch also mentioned that one of his future directives is to look at the differences in the transcriptome and proteome.
My question is, how would a multi-omic analysis benefit Dr. Asch's study, or really any study in general?
I found Dr. Asch's presentation to be very interesting to learn about as I have always been curious about the type of research he does.
For Anna's question, I believe that if there were not any model organisms we would be impacted very largely in terms of research. A lot of scientific discoveries would not have been obtained and we would have a very poor understanding on the way cells carry out their functions.
For Frank's question, I think using multi-omic analysis would be able to save a lot of time for determining biomarkers within the data and this could lead to further analysis/studies because this would give stronger confidence in their results.
I enjoyed Dr. Asch's presentation and learning about his work with Neurospora crassa, especially as a supplement to my coursework in his advanced molecular genetics course this semester.
For Anna's question, if there were not any model organisms for biological research, I believe we would be many years behind in many aspects. I think that we might have detailed knowledge about some specific areas, but we would have less understanding of the interactions between systems within organisms, and we may not have even sequenced a whole genome yet! Model organisms allow us to study simple systems in completion, and our findings advance our knowledge of all organisms.
For Frank's question, a multi-omic analysis would reveal the fine details involved in gene the regulation and expression. Being able to directly compare the genome, transcriptome, and proteome of an organism of interest would allow one to quickly identify key rate-limiting steps in regulation, and design more detailed studies to hone in on the exact mechanisms and proteins involved.
Dr. Asch's presentation was very informative, his work with Neurospora crassa is intriguing. I loved how he mentioned what path his students took post-graduation. Their success is encouraging and speaks greatly of Dr. Asch as a mentor!
To answer Anna's question, without model organisms I doubt science would be as developed as it is currently. Model organisms allows us to gain insight on the interactions occurring within organisms and then use this information to make inferences or other discoveries.
In reference to Frank's question, a multi-omic analysis could increase the efficiency in means of both time and accuracy. Utilizing this would make finding biomarkers easier since you are analyzing the complex, multiple omes all at once.
Like all of the presenters that we have seen this semester in seminar, I thought Dr. Asch delivered a very interesting presentation on his research.
For Anna's question, I think not having a model organism would create many unwanted obstacles. As others have mentioned, the research involved with these organisms would probably not be at the advanced level that it is today. Scientists would have to attempt to find some type of species that is relatively easy to work with and wouldn't present many confounding variables in their experiments, which would be a difficult task.
As for Franks's question, I do think that a multi-omic analysis would definitely increase efficiency to Dr. Asch's study, or other studies in general. The integration of multi-omic data, will make understanding the relationships of these fields and understanding their overall impact on biological mechanisms much easier and effective.
I found Dr. Asch's presentation to be very interesting and informative and I enjoyed learning about his work with Neurospora crassa. It was also nice to hear about where his students are now.
To answer Anna's question, without model organisms scientific discovery and research would be largely impacted. Science would be set back since model organisms allow scientists to understand the biological processes within a laboratory setting. This results in advances in understanding particular organisms or to further scientific discoveries.
As for Frank's question, a multi-omic analysis would be able detect functional relationships within samples by directly comparing the genome, proteome, transcriptome, and the epigenome. This would increase the chances of finding important biomarkers within a particular species.
If there were no model organisms science would suffer greatly. There has been an enormous amount of data and understanding gained through the use of model organisms. Who knows how many decades behind research would be without model organisms. Model organisms are generally highly controlled, meaning you can more easily find and test variables without to much noise. They are also generally cheap, meaning many scientists, regardless of funding, can use them. Overall, I think that without the use of model organisms we would not know anywhere near the amount of data we know today.
I enjoyed Dr. Asch's presentation. I also really like that he added where some of his former students are now and what they're doing. As far as the model organism question goes, I do believe that research would be affected greatly. This is because there has been so much research using different model organisms. There would be a lot less understanding of specific organisms. For Frank's question, multi-omic analysis would be greatly beneficial. I agree with most of the other answers in that it would improve efficiency and understanding.
I enjoyed the information provided at the end of his lecture in regards to where his past grad students are now. It is interesting to see how YSU Alumni have progressed in their careers post-graduation and how lab work and the mastering of lab techniques helped them in their careers. Something that is not always given a lot of thought when going through the daily struggle of grad school.
ReplyDeleteDr. Asch gave a very interesting talk on the research going on in his lab. He does a lot of work with the model organism, Neurospora crassa, which grows rapidly, is easy to culture, and requires minimum growth media. Dr. Asch looks specifically at the effects of quinic acid and dextrose exposure on N. crassa. He uses a variety of analysis techniques for his samples including mass spectrometry and qRT-PCR with fluorescent markers. The use of bioinformatics is very critical to the analysis, so he works closely with Dr. Min.
In your opinion, if, there was not model organisms, such as Neurospora crassa, how would scientific research be effected?
Anna and I are working in tandem on this one.
ReplyDeleteAs the semester draws to a close, its good to see that regardless of the path each speaker took, or how long it took them to reach their goals, they eventually were able to reach their academic or professional goals. It gives me a sense of hope to know that all the time and resources i'm investing will pay dividends down the road.
Another overarching theme amongst presenters was their use of molecular biology, bioinformatics, and statistics as tools to provide them with useful data for analysis. Dr. Asch utilized microarrys to do bulk expression analysis on Quinic Acid expression. however, Dr. Asch also mentioned that one of his future directives is to look at the differences in the transcriptome and proteome.
My question is, how would a multi-omic analysis benefit Dr. Asch's study, or really any study in general?
I found Dr. Asch's presentation to be very interesting to learn about as I have always been curious about the type of research he does.
ReplyDeleteFor Anna's question, I believe that if there were not any model organisms we would be impacted very largely in terms of research. A lot of scientific discoveries would not have been obtained and we would have a very poor understanding on the way cells carry out their functions.
For Frank's question, I think using multi-omic analysis would be able to save a lot of time for determining biomarkers within the data and this could lead to further analysis/studies because this would give stronger confidence in their results.
I enjoyed Dr. Asch's presentation and learning about his work with Neurospora crassa, especially as a supplement to my coursework in his advanced molecular genetics course this semester.
ReplyDeleteFor Anna's question, if there were not any model organisms for biological research, I believe we would be many years behind in many aspects. I think that we might have detailed knowledge about some specific areas, but we would have less understanding of the interactions between systems within organisms, and we may not have even sequenced a whole genome yet! Model organisms allow us to study simple systems in completion, and our findings advance our knowledge of all organisms.
For Frank's question, a multi-omic analysis would reveal the fine details involved in gene the regulation and expression. Being able to directly compare the genome, transcriptome, and proteome of an organism of interest would allow one to quickly identify key rate-limiting steps in regulation, and design more detailed studies to hone in on the exact mechanisms and proteins involved.
Dr. Asch's presentation was very informative, his work with Neurospora crassa is intriguing. I loved how he mentioned what path his students took post-graduation. Their success is encouraging and speaks greatly of Dr. Asch as a mentor!
ReplyDeleteTo answer Anna's question, without model organisms I doubt science would be as developed as it is currently. Model organisms allows us to gain insight on the interactions occurring within organisms and then use this information to make inferences or other discoveries.
In reference to Frank's question, a multi-omic analysis could increase the efficiency in means of both time and accuracy. Utilizing this would make finding biomarkers easier since you are analyzing the complex, multiple omes all at once.
Like all of the presenters that we have seen this semester in seminar, I thought Dr. Asch delivered a very interesting presentation on his research.
ReplyDeleteFor Anna's question, I think not having a model organism would create many unwanted obstacles. As others have mentioned, the research involved with these organisms would probably not be at the advanced level that it is today. Scientists would have to attempt to find some type of species that is relatively easy to work with and wouldn't present many confounding variables in their experiments, which would be a difficult task.
As for Franks's question, I do think that a multi-omic analysis would definitely increase efficiency to Dr. Asch's study, or other studies in general. The integration of multi-omic data, will make understanding the relationships of these fields and understanding their overall impact on biological mechanisms much easier and effective.
I found Dr. Asch's presentation to be very interesting and informative and I enjoyed learning about his work with Neurospora crassa. It was also nice to hear about where his students are now.
ReplyDeleteTo answer Anna's question, without model organisms scientific discovery and research would be largely impacted. Science would be set back since model organisms allow scientists to understand the biological processes within a laboratory setting. This results in advances in understanding particular organisms or to further scientific discoveries.
As for Frank's question, a multi-omic analysis would be able detect functional relationships within samples by directly comparing the genome, proteome, transcriptome, and the epigenome. This would increase the chances of finding important biomarkers within a particular species.
If there were no model organisms science would suffer greatly. There has been an enormous amount of data and understanding gained through the use of model organisms. Who knows how many decades behind research would be without model organisms. Model organisms are generally highly controlled, meaning you can more easily find and test variables without to much noise. They are also generally cheap, meaning many scientists, regardless of funding, can use them. Overall, I think that without the use of model organisms we would not know anywhere near the amount of data we know today.
ReplyDeleteI enjoyed Dr. Asch's presentation. I also really like that he added where some of his former students are now and what they're doing.
ReplyDeleteAs far as the model organism question goes, I do believe that research would be affected greatly. This is because there has been so much research using different model organisms. There would be a lot less understanding of specific organisms.
For Frank's question, multi-omic analysis would be greatly beneficial. I agree with most of the other answers in that it would improve efficiency and understanding.
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