This blog is devoted to BIOL 6988, a graduate level seminar in the biological sciences at Youngstown State University. While targeted towards graduate students, BIOL 6988 actively incorporates undergraduate participants in their scholastic endeavors in the biological sciences. This blog is intended as a educational tool not just for YSU students and faculty, but for anyone who wishes to contribute to an active-learning environment.
Dr. Asch’s presentation was very insightful. He did his presentation on changes in the fungal gene expression in response growth on quinic acid. He chose his model system to be the fungus Neurospora crass. It is a main species used in molecular and genetic studies. It grows in moist, high climate regions and has an asexual life cycle. During his studies, he found that working using microarrays had shown that the exposure to quinic acid had effects on gene expression well beyond the quinic acid gene cluster. After isolating the proteins, the protein found was that of NCU 08332. This protein was of special interest because it also appeared in a study of Nitrogen sources. At the end of Dr. Asch’s presentation he listed future projects. Some of these included conformation of proteome changes using qPCR, kinetics of quince acid gene expression, examination of differing nitrogen sources effects on the proteome, evolution of the quince acid gene cluster in fungi.
Which of these projects seem most exciting to you, and why?
Dr. Asch gave a very interesting presentation on the changes of fungal gene expression in the presence of quinic acid. Out of the potential future projects that Dr. Asch listed, I would be most interested in the evolution of the quinic acid gene cluster in fungi. Upon microarray analysis, Dr. Asch discovered that quinic acid affected the quinic acid gene cluster expression and the expression of some other genes as well. Diving deeper into the evolution of the quinic acid gene cluster in fungi in the presence of quinic acid could provide insight on how quinic acid affects gene expression of other genes in fungi.
I really enjoyed Dr. Asch's presentation on fungal gene expression. Out of the future projects listed, the evolution of the quinic acid gene cluster in fungi is most exciting to me. By using bioinformatics tools, one can analyze a protein database to find homologues of a specific protein, align those multiple sequences, and place the proteins on tree to observe their evolutionary relationships. This interests me because of my experience in Dr. Min's course performing these types of analyses. Evolutionary relationships may reveal more functions of the proteins, as well.
I enjoyed Dr. Asch's presentation on Gene Expression in Neurospora crassa in Response to Nutritional Resources. The variable that he was looking at and changing was the response in growth depending on quinic acid.
He chose Neurospora because it is a common and main species that is used in many molecular and genetic studies. Out of the future projects he listed, I would be most interested in the evolution of the quinic acid gene cluster
in fungi. I typically study evolution on the organism level of life, but I think it would be interesting to study it on a molecular level.
Dr. Asch's presentation on gene expression in Neurospora crassa in response to nutritional resources was captivating.
Looking at fungal expression in response growth to quinic acid, I would love to research further on conformation of proteome changes using qPCR. With this study I would be able to quantify the gene expression in fungi as it responds to quinic acid growth.
Dr. Asch’s presentation was very insightful. He did his presentation on changes in the fungal gene expression in response growth on quinic acid. He chose his model system to be the fungus Neurospora crass. It is a main species used in molecular and genetic studies. It grows in moist, high climate regions and has an asexual life cycle. During his studies, he found that working using microarrays had shown that the exposure to quinic acid had effects on gene expression well beyond the quinic acid gene cluster. After isolating the proteins, the protein found was that of NCU 08332. This protein was of special interest because it also appeared in a study of Nitrogen sources.
ReplyDeleteAt the end of Dr. Asch’s presentation he listed future projects. Some of these included conformation of proteome changes using qPCR, kinetics of quince acid gene expression, examination of differing nitrogen sources effects on the proteome, evolution of the quince acid gene cluster in fungi.
Which of these projects seem most exciting to you, and why?
Dr. Asch gave a very interesting presentation on the changes of fungal gene expression in the presence of quinic acid. Out of the potential future projects that Dr. Asch listed, I would be most interested in the evolution of the quinic acid gene cluster in fungi. Upon microarray analysis, Dr. Asch discovered that quinic acid affected the quinic acid gene cluster expression and the expression of some other genes as well. Diving deeper into the evolution of the quinic acid gene cluster in fungi in the presence of quinic acid could provide insight on how quinic acid affects gene expression of other genes in fungi.
ReplyDeleteI really enjoyed Dr. Asch's presentation on fungal gene expression. Out of the future projects listed, the evolution of the quinic acid gene cluster in fungi is most exciting to me. By using bioinformatics tools, one can analyze a protein database to find homologues of a specific protein, align those multiple sequences, and place the proteins on tree to observe their evolutionary relationships. This interests me because of my experience in Dr. Min's course performing these types of analyses. Evolutionary relationships may reveal more functions of the proteins, as well.
ReplyDeleteI enjoyed Dr. Asch's presentation on Gene Expression in Neurospora crassa in Response to Nutritional Resources. The variable that he was looking at and changing was the response in growth depending on quinic acid.
ReplyDeleteHe chose Neurospora because it is a common and main species that is used in many molecular and genetic studies. Out of the future projects he listed, I would be most interested in the evolution of the quinic acid gene cluster
in fungi. I typically study evolution on the organism level of life, but I think it would be interesting to study it on a molecular level.
Dr. Asch's presentation on gene expression in Neurospora crassa in response to nutritional resources was captivating.
ReplyDeleteLooking at fungal expression in response growth to quinic acid, I would love to research further on conformation of proteome changes using qPCR. With this study I would be able to quantify the gene expression in fungi as it responds to quinic acid growth.