This blog is devoted to BIOL 6988, a graduate level seminar in the biological sciences at Youngstown State University. While targeted towards graduate students, BIOL 6988 actively incorporates undergraduate participants in their scholastic endeavors in the biological sciences. This blog is intended as a educational tool not just for YSU students and faculty, but for anyone who wishes to contribute to an active-learning environment.
Due to the coronavirus pandemic, Olivia shall send out her presentation as
a voice-over PowerPoint. This post represents the spot where grad
students in BIOL 6988 are to comment on her presentation.
I enjoyed Olivia's talk. The idea of cancer is such a nasty thought and is unfortunately becoming more and more present in our lives. I appreciate the idea of using new materials and substances to try to find anti-cancer properties and novel treatments. I'd like to know how the original substances were made and how they were extracted from the plant, just for the sake of the chemistry. It's unfortunate that the data was shown wasn't her own, but I don't doubt that there was data in another file format that was similar to that which was presented. It might not have been a bad idea to elaborate a bit more on the data shown since I think not everyone has seen flow data and can interpret it. I only recently learned about it and I would have liked to have been told the parameters of the gating and grouping of the data points and how much data can be gleaned from that cluster of dots. Overall, good job. Easy to listen to, could follow along with relative ease.
I agree with you on the fact that Olivia's presentation was very easy to follow along with. However, I just wanted to mention that only one picture in her presentation was not hers, and she only used it because she was unable to open her own results due to the fact that she cannot go to campus to convert the file! She only used it as a visual aid :)
I loved how Olivia handled her presentation. Cancer being a leading cause of death worldwide,it was a good idea for her to look into drug discovery especially the anti-cancer properties of Podophyllotoxin. As more research is being done on proper diagnostic methods and better drugs,people should be enlightened on their dietary lifestyles as a preventive measure. It was also interesting learning the steps she took in her research. Awesome work.
Olivia's presentation was very informative and I also found it fairly easy to follow. With numerous cancer treatments having some negative side effects, it is interesting to see how these findings can turn to a more natural treatments that are not harmful to the human body. While the data was the only bit of her presentation that was a bit hard to follow, Olivia's findings offer a great start towards developing natural cancer treatments. - Michael Deak
Olivia's presentation was over the anticancer properties of podophyllotoxin analogues in hopes for finding more holistic drug therapies. She opened up by explaining what cancer is and how it develops through genetic mutation, which may cause cell cycle damage, which ultimately leads to abnormal proliferation. She next went over foods that increase and decrease risk of cancer and went over the importance of using natural products for medicine, since natural foods/products have anticancer properties. Podophyllotoxin is known to have anticancer properties to inhibit tubulin polymerization, so Olivia's project is focussed on discovering new anticancer properties of podophyllotoxin analogues. She is able to do this by looking at cell viability, MTT Assay, looking at IC50 values, and then being able to look at apoptosis induction or cell cycle control inhibition. Other than the five cancer cell lines that she tested, what other cell line do you think would be interesting to see results on?
Since the podophyllotoxin is known to have toxic effects in the kidneys and liver, I think that studying the Cacci-1 or Cacci-2 and the Hep G2 or Hep 3B cell lines would be good to study. The effects of a particular concentration on Olivia's test cell lines could be compared to the kidney and liver cell lines and possibly elucidate dosing concentrations that achieve a favorable balance between target cancer death and toxic effects on healthy cells.
The presentation overall was informative and transitioned well between Olivia's points of discussion. I am interested to see what results this project will produce in the future.
Excellent presentation. Cancer is serious business, and I'm always excited to hear about alternate approaches to treatment. If we could earnestly move away from current cancer treatments which can be harmful that would be ideal. Podophyllotoxin and its analogues seem promising, and further along in the future I would be interested to see how this approach fares in a clinical setting.
Olivia gave a very good presentation and it was very easy to follow. As everyone has already said, cancer research is no joke. I enjoy presentations that are bio-medically driven. I am curious to see future results and what direction you decide to take this research in. It would also be interesting to incorporate kidney cells in your treatment options as Errek stated. I wonder how that would turn out???
Olivia presentation on cancer research was interesting to know, learned about the anticancer properties of Podophyllotoxin and its analogues which can be used in future for better development of cancerous drugs. Podophyllotoxin is derived from plants similar to the other drugs used in cancer treatment it would be interesting to know how this can be used in future clinical trials
Olivia’s presentation on the affects of podophyllotoxin analogues on various cancer cell lines was well done. The PowerPoint had wonderful pictures/graphics and was appealing to the eye. Olivia also made it easy to follow along with her research, which is impressive since some of it can be quite complicated in lab. Cancer research is one of the most important areas of research in the biomedical field and finding a drug that minimizes its effect on healthy cells while maximizing its effect on cancer cells would be the dream.
Olivia gave a wonderful presentation. The adaptation of including previous data in the unexpected speed-bump of not being able to access her files is commendable. I enjoyed hearing the conclusions and final analyses of her research as I have shared a lab with her for 2 years. Olivia is a talented and experienced orator making her presentation easy to follow and very engaging.
I enjoyed Olivia's talk. The idea of cancer is such a nasty thought and is unfortunately becoming more and more present in our lives. I appreciate the idea of using new materials and substances to try to find anti-cancer properties and novel treatments. I'd like to know how the original substances were made and how they were extracted from the plant, just for the sake of the chemistry.
ReplyDeleteIt's unfortunate that the data was shown wasn't her own, but I don't doubt that there was data in another file format that was similar to that which was presented. It might not have been a bad idea to elaborate a bit more on the data shown since I think not everyone has seen flow data and can interpret it. I only recently learned about it and I would have liked to have been told the parameters of the gating and grouping of the data points and how much data can be gleaned from that cluster of dots.
Overall, good job. Easy to listen to, could follow along with relative ease.
I agree with you on the fact that Olivia's presentation was very easy to follow along with. However, I just wanted to mention that only one picture in her presentation was not hers, and she only used it because she was unable to open her own results due to the fact that she cannot go to campus to convert the file! She only used it as a visual aid :)
DeleteI loved how Olivia handled her presentation. Cancer being a leading cause of death worldwide,it was a good idea for her to look into drug discovery especially the anti-cancer properties of Podophyllotoxin. As more research is being done on proper diagnostic methods and better drugs,people should be enlightened on their dietary lifestyles as a preventive measure. It was also interesting learning the steps she took in her research. Awesome work.
ReplyDeleteOlivia's presentation was very informative and I also found it fairly easy to follow. With numerous cancer treatments having some negative side effects, it is interesting to see how these findings can turn to a more natural treatments that are not harmful to the human body. While the data was the only bit of her presentation that was a bit hard to follow, Olivia's findings offer a great start towards developing natural cancer treatments. - Michael Deak
ReplyDeleteOlivia's presentation was over the anticancer properties of podophyllotoxin analogues in hopes for finding more holistic drug therapies. She opened up by explaining what cancer is and how it develops through genetic mutation, which may cause cell cycle damage, which ultimately leads to abnormal proliferation. She next went over foods that increase and decrease risk of cancer and went over the importance of using natural products for medicine, since natural foods/products have anticancer properties. Podophyllotoxin is known to have anticancer properties to inhibit tubulin polymerization, so Olivia's project is focussed on discovering new anticancer properties of podophyllotoxin analogues. She is able to do this by looking at cell viability, MTT Assay, looking at IC50 values, and then being able to look at apoptosis induction or cell cycle control inhibition. Other than the five cancer cell lines that she tested, what other cell line do you think would be interesting to see results on?
ReplyDeleteSince the podophyllotoxin is known to have toxic effects in the kidneys and liver, I think that studying the Cacci-1 or Cacci-2 and the Hep G2 or Hep 3B cell lines would be good to study. The effects of a particular concentration on Olivia's test cell lines could be compared to the kidney and liver cell lines and possibly elucidate dosing concentrations that achieve a favorable balance between target cancer death and toxic effects on healthy cells.
DeleteThe presentation overall was informative and transitioned well between Olivia's points of discussion. I am interested to see what results this project will produce in the future.
Okay, I misspelled the kidney cells lines. They are Caki-1 and Caki-2.
DeleteExcellent presentation. Cancer is serious business, and I'm always excited to hear about alternate approaches to treatment. If we could earnestly move away from current cancer treatments which can be harmful that would be ideal. Podophyllotoxin and its analogues seem promising, and further along in the future I would be interested to see how this approach fares in a clinical setting.
ReplyDeleteOlivia gave a very good presentation and it was very easy to follow. As everyone has already said, cancer research is no joke. I enjoy presentations that are bio-medically driven. I am curious to see future results and what direction you decide to take this research in. It would also be interesting to incorporate kidney cells in your treatment options as Errek stated. I wonder how that would turn out???
ReplyDeleteOlivia presentation on cancer research was interesting to know, learned about the anticancer properties of Podophyllotoxin and its analogues which can be used in future for better development of cancerous drugs. Podophyllotoxin is derived from plants similar to the other drugs used in cancer treatment it would be interesting to know how this can be used in future clinical trials
ReplyDeleteOlivia’s presentation on the affects of podophyllotoxin analogues on various cancer cell lines was well done. The PowerPoint had wonderful pictures/graphics and was appealing to the eye. Olivia also made it easy to follow along with her research, which is impressive since some of it can be quite complicated in lab. Cancer research is one of the most important areas of research in the biomedical field and finding a drug that minimizes its effect on healthy cells while maximizing its effect on cancer cells would be the dream.
ReplyDeleteOlivia gave a wonderful presentation. The adaptation of including previous data in the unexpected speed-bump of not being able to access her files is commendable. I enjoyed hearing the conclusions and final analyses of her research as I have shared a lab with her for 2 years. Olivia is a talented and experienced orator making her presentation easy to follow and very engaging.
ReplyDeletemykaela wagner
Delete